Our data suggests that modified NC-FET protocol has comparable pregnancy outcomes to down-regulated HC-FET when utilizing frozen-thawed day 5 embryos.īlastocysts Frozen-thawed embryo transfer Hormonally controlled cycles Natural cycle. An age analysis within three age groups (≤35, 36-39, ≥40) was performed, but no significant difference in clinical pregnancy was observed. 43.6%) between modified NC-FET and HC-FET. Analysis of the first cycle pregnancy outcomes revealed no significant differences in clinical pregnancy rate (54.3% vs. Mean age (years), day-3 FSH levels (mIU/mL) and percentage of patients with male factor infertility were significantly higher and mean BMI (kg/m 2) was significantly lower in modified NC-FET compared to HC-FET, respectively. There were 197 patients in the modified NC-FET protocol and 181 in the down-regulated HC-FET protocol. The primary outcomes included clinical pregnancy and delivery rates. Blastocyst FET was planned 6days after initiating P4. Once serum E2 levels reached >500pg/mL and endometrial lining reached >8mm, intramuscular (IM) P4 in oil was administered. Exogenous estradiol was initiated on the third day of menses. both meds continue during 2ww on schedule. Lining check, then the PIO shots for 6 days (while continuing the estradiol every 3rd day). These patients were placed on medroxy-progesterone acetate (10mg) for 10days to bring on menses and were also given a half-dose of GnRH-agonist (GnRH-a) on the third day of medroxy-progesterone acetate. Then Del estradiol (estrogen) shots every 3 days for 2weeks. Anovulatory patients and some ovulatory patients underwent down-regulated HC-FET. Vaginal progesterone (P4) was started two days later and blastocyst transfer was planned seven days after detecting the LH surge. These patients were given hCG 10,000 IU IM on the day of LH-surge. Patients with regular menses and evidence of ovulation underwent modified NC-FET. Four hundred twenty eight patients underwent a total of 493 FET cycles. Serum E2, LH and P4 is measured beginning on day 8-10 when the leading follicle is about 15 mm in size. Cycles can be canceled if P4 is more than 1.5 ng/ml (5 nmol/L) on these days. Cycles with donor blastocysts were excluded. True natural cycle FET protocol For a true natural cycle, an ultrasound is performed on CD2 or CD3 to ensure the corpus luteum from the previous cycle is gone. This retrospective cohort study included all patients undergoing either modified NC-FET or down-regulated HC-FET using frozen-thawed day 5 embryos. To describe pregnancy outcomes of frozen-thawed blastocysts cycles using modified natural cycle frozen embryo transfers (NC-FET) and down-regulated hormonally controlled frozen embryo transfers (HC-FET) protocols.
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